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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
1977-2-16
|
| pubmed:abstractText |
The methyl moiety of ribothymidine in the tRNA of Streptococcus faecalis, Bacillus subtilis, and probably Bacillus cereus is dervied from a 1-carbon folate derivative and not S-adenosylmethionine. Micrococcus luteus (M. lysodeikticus) tRNA appears to be almost devoid of ribothymidine. S. faecalis tRNA lacking ribothymidine can be methylated in vitro with formation of ribothymidine. 5,10-Methylenetetrahydrofolate has been identified as the 1-carbon donor involved in ribothymidine formation in S. faecalis and implicated in the analogous reaction in B. subtilis. The reaction requires FADH2 and/or another reducing agent present in cell extracts for the reduction of the methylene moiety.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
251
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7649-56
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:826533-Bacillus subtilis,
pubmed-meshheading:826533-Enterococcus faecalis,
pubmed-meshheading:826533-Kinetics,
pubmed-meshheading:826533-RNA, Transfer,
pubmed-meshheading:826533-Ribonucleosides,
pubmed-meshheading:826533-Species Specificity,
pubmed-meshheading:826533-Tetrahydrofolates,
pubmed-meshheading:826533-Uridine,
pubmed-meshheading:826533-Urine
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Biosynthesis of ribothymidine in the transfer RNA of Streptococcus faecalis and Bacillus subtilis. A methylation of RNA involving 5,10-methylenetetrahydrofolate.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|