Linked Life Data

8264507

Source:http://linkedlifedata.com/resource/pubmed/id/8264507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1994-1-24
pubmed:abstractText
Magnesium is essentially an intracellular cation, which makes it difficult to evaluate magnesium status. About 1% of total body magnesium is present in serum and interstitial body fluid and only about 1% of the intracellular magnesium is in the free form, Mg2+. Recent studies show that this small fraction of free Mg2+ rapidly changes with the extracellular magnesium. These free Mg2+ levels are carefully controlled within the cell and total cellular magnesium content are maintained at the expense of extracellular fluid and bone magnesium levels. Regulation of magnesium balance is met between intestinal absorption and renal excretion. The excretory side of magnesium balance involves appropriate changes in renal magnesium handling. Present evidence indicates that renal handling of magnesium normally is a filtration-reabsorption process; magnesium is filtered at the glomerulus and reabsorbed along the various segments making up the renal nephron. About 80% of total serum magnesium (0.7-1 mmol/l) is filtered at the glomerular membrane. Of the ultrafilterable magnesium (0.6-0.8 mmol/l) 20-25% is reabsorbed by the proximal tubule, including the convoluted and straight portions. Some 50-60% of the filtered magnesium is reabsorbed in the loop of Henle, specifically by thick ascending limb cells. The terminal nephron segments, including the distal convoluted tubule and collecting ducts, reabsorb only a small portion of the filtered magnesium (about 5-10%). The loop of Henle plays the major role in determining magnesium reabsorption and urinary magnesium excretion. The loop of Henle also is the segment in which the major regulatory factors act to maintain magnesium balance.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-0392
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
218-25
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Magnesium homeostasis and renal magnesium handling.
pubmed:affiliation
Department of Medicine, University of British Columbia, University Hospital, Vancouver, Canada.
pubmed:publicationType
Journal Article, Review