Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-1-26
pubmed:abstractText
Cultured epidermal allografts have been successfully used to treat a wide variety of skin defects ranging from burns to leg ulcers. Their postulated mechanism of action is through release of multiple cytokines that stimulate epithelialization from the wound periphery as well as from remnant epidermal appendages. A randomized, controlled clinical trial was undertaken to compare the efficacy of cryopreserved cultured allograft dressings (CCAD) with tulle-gras dressings in the treatment of split-skin graft donor sites. Five patients were enrolled in the study and in each patient, half of the donor site was allografted and the other half was treated with tulle-gras control. The mean time to complete healing was 6.2 days for CCAD compared with 9.6 days (p = 0.035) for the tulle-gras controls. Patient assessment of pain with dressing changes was also significantly lower at the CCAD-treated sites than at the control sites (p = 0.001). The results indicate that cultured allografts offer greater patient comfort and earlier maturation of regenerated skin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-5282
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
850-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8263981-Adult, pubmed-meshheading:8263981-Aged, pubmed-meshheading:8263981-Anti-Infective Agents, Local, pubmed-meshheading:8263981-Bandages, pubmed-meshheading:8263981-Biological Dressings, pubmed-meshheading:8263981-Cryopreservation, pubmed-meshheading:8263981-Culture Techniques, pubmed-meshheading:8263981-Female, pubmed-meshheading:8263981-Humans, pubmed-meshheading:8263981-Incidence, pubmed-meshheading:8263981-Male, pubmed-meshheading:8263981-Middle Aged, pubmed-meshheading:8263981-Pain, pubmed-meshheading:8263981-Pain Measurement, pubmed-meshheading:8263981-Phenols, pubmed-meshheading:8263981-Prospective Studies, pubmed-meshheading:8263981-Single-Blind Method, pubmed-meshheading:8263981-Skin Transplantation, pubmed-meshheading:8263981-Surgical Wound Infection, pubmed-meshheading:8263981-Tissue Donors, pubmed-meshheading:8263981-Wound Healing
pubmed:year
1993
pubmed:articleTitle
Randomized trial comparing cryopreserved cultured epidermal allografts with tulle-gras in the treatment of split-thickness skin graft donor sites.
pubmed:affiliation
Department of Dermatology, Ziekenhuis Leyenburg, Den Haag, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial