Linked Life Data

8263655

Source:http://linkedlifedata.com/resource/pubmed/id/8263655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-1-27
pubmed:abstractText
Age-related changes in cerebral hyaluronic acid (HA) and chondroitin sulfate (CS) in senescence-accelerated mice (SAM-P/8 parallel Odu, P substrain) were investigated. SAM-R/1 parallel Odu (R substrain) mice were used as controls. Levels of both HA and CS extracted from the defatted dry cerebrums at 7, 17, 27 and 37 weeks of age were determined by HPLC analysis after conversion to unsaturated disaccharides following enzymatic digestion. Glycosaminoglycan content (determined as uronic acid) was lower in P substrain mice than in the age-matched controls at all ages tested. Though the ratio of HA to CS was increased at 17 and 27 weeks in control mice, this ratio for the P substrain was already high at the initial test at 7 weeks and remained so thereafter. The CS chain consisted mainly of delta Di-4S, with delta Di-0S and delta Di-6S present only as minor components at all ages in both substrains. The HA chain consisted only of delta Di-HA for all ages in both substrains. The relative amount of each unsaturated disaccharide was higher in the R substrain than in the P substrain mice at all ages. We found that qualitative and quantitative changes in cerebral CS and HA were expressed relatively early in the P substrain mice compared to controls. We propose that these changes are associated with and may cause physiological and functional alterations associated with senescence in the CNS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0475-2058
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-49
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Age-related changes in central nervous system hyaluronic acid and chondroitin sulfate in senescence-accelerated mice.
pubmed:affiliation
Department of Biochemistry, Osaka Dental University, Japan.
pubmed:publicationType
Journal Article