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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-1-21
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pubmed:abstractText |
Various studies have provided evidence that peripheral T-cells from the diabetes-prone BB-DP rat are abnormal in function and cell surface phenotype. These characteristics have often been interpreted as indicators of immaturity and/or short life span. In this study, we describe a CD4-dependent signaling abnormality in BB-DP peripheral T-cells. In spite of the fact that CD4 plays a critical role in thymocyte development, the abnormal signaling does not appear to influence thymocyte development at the stage when the T-cell receptor is rearranged and the recombinase enzymes RAG-1 and RAG-2 transcripts are downregulated. Therefore, if a maturation defect leading to the seeding of the periphery with immature T-cells occurs in the BB-DP rat, it does not preclude the initial selection of the self major histocompatibility complex-restricted T-cell repertoire.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Nucleotidyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinases,
http://linkedlifedata.com/resource/pubmed/chemical/V(D)J recombination activating...,
http://linkedlifedata.com/resource/pubmed/chemical/integron integrase IntI1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-52
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8262316-Animals,
pubmed-meshheading:8262316-Antigens, CD4,
pubmed-meshheading:8262316-Apoptosis,
pubmed-meshheading:8262316-DNA Nucleotidyltransferases,
pubmed-meshheading:8262316-DNA-Binding Proteins,
pubmed-meshheading:8262316-Diabetes Mellitus, Type 1,
pubmed-meshheading:8262316-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:8262316-Homeodomain Proteins,
pubmed-meshheading:8262316-Integrases,
pubmed-meshheading:8262316-Lymphocyte Activation,
pubmed-meshheading:8262316-Major Histocompatibility Complex,
pubmed-meshheading:8262316-Protein Biosynthesis,
pubmed-meshheading:8262316-Proteins,
pubmed-meshheading:8262316-Rats,
pubmed-meshheading:8262316-Rats, Inbred BB,
pubmed-meshheading:8262316-Rats, Inbred WF,
pubmed-meshheading:8262316-Recombinases,
pubmed-meshheading:8262316-Signal Transduction,
pubmed-meshheading:8262316-T-Lymphocyte Subsets,
pubmed-meshheading:8262316-T-Lymphocytes,
pubmed-meshheading:8262316-Transcription, Genetic
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pubmed:year |
1994
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pubmed:articleTitle |
Peculiar T-cell signaling does not preclude positive selection in the diabetes-prone BB rat.
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pubmed:affiliation |
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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