Linked Life Data

8261641

Source:http://linkedlifedata.com/resource/pubmed/id/8261641

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-1-27
pubmed:abstractText
The Contingent Negative Variation (CNV) may measure arousal and attention, and is affected by various dopaminergic disorders. We recorded CNVs in 12 patients fulfilling diagnostic criteria of Gilles de la Tourette Syndrome (TS). Ten of 12 patients were male, 10 had attention deficit disorder (ADD), and 3 also had obsessions and compulsions (OCD). Medication had been stopped or TS treatment not yet started. TS patients had higher CNV amplitude and more frequent postimperative negative variation than controls. CNV2 was enhanced in all TS patients, while CNV1 was attenuated in TS patients with ADD or OCD. This suggests that CNV may be increased in TS, mostly because of CNV2 and perhaps due to dopaminergic excess. CNV2, considered to reflect adrenergic arousal mechanisms, may be effected by neurobehavioral concomitants of TS. Neurophysiological categorization of TS patients may be possible and valuable.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-9155
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
188-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Contingent negative variation in Gilles de la Tourette syndrome.
pubmed:affiliation
Department of Neurology, Ohio State University Hospitals, Columbus 43210.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't