| pubmed-article:8260359 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0040669 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0039286 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C0332283 | lld:lifeskim |
| pubmed-article:8260359 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8260359 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8260359 | pubmed:dateCreated | 1994-1-21 | lld:pubmed |
| pubmed-article:8260359 | pubmed:abstractText | A tamoxifen resistant cell line (clone 9) has been isolated from the tamoxifen sensitive, hormone responsive MCF-7 breast carcinoma cell line after transfection with mixed cDNA libraries, followed by tamoxifen selection in the presence of oestrogens. Transfection was confirmed by Southern analysis with vector probes. Clone 9 in several-fold more resistant to tamoxifen and other anti-oestrogens than wild type cells when cultured either as a monolayer or as colonies in soft agar but retains oestrogen receptors. Clone 9 was less responsive to 17-beta-oestradiol than were wild type MCF-7. In addition to showing in vitro tamoxifen resistance, clone 9 was also tamoxifen resistant in vivo when xenografted into the nude mouse. Culture medium conditioned by clone 9 cells stimulated quiescent cells of the same clone as well as wild type cells, whereas medium conditioned by wild type MCF-7 was inhibitory to both, suggesting that clone 9 may be secreting an autocrine growth factor. Clone 9 provides a novel model for further investigation of the mechanism of anti-oestrogen resistance that occurs without loss of oestrogen receptors. Preliminary results suggest that an autocrine growth stimulatory mechanism may be one pathway of such resistance. | lld:pubmed |
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| pubmed-article:8260359 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8260359 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8260359 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8260359 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8260359 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:8260359 | pubmed:author | pubmed-author:HarrisA LAL | lld:pubmed |
| pubmed-article:8260359 | pubmed:author | pubmed-author:ToiMM | lld:pubmed |
| pubmed-article:8260359 | pubmed:author | pubmed-author:BicknellRR | lld:pubmed |
| pubmed-article:8260359 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8260359 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:8260359 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8260359 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8260359 | pubmed:pagination | 1088-96 | lld:pubmed |
| pubmed-article:8260359 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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