Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1994-1-14
|
| pubmed:abstractText |
To examine the development of T cells within an allogeneic or xenogeneic environment, we engrafted the fetal thymus from AKR mice or F344 rats under the kidney capsule of SCID mice (mTG and rTG mice). T lymphopoiesis developed in SCID mice 2 months after transplantation, although the ratio of CD4/CD8 in both experimental groups was different from that of normal control. T cells in mTG mice did not show in vitro proliferation or cytotoxicity against either host-type C.B-17 (H-2d) or donor-type AKR (H-2k) cells, while they exerted potent activities against third-party B10 (H-2b) cells. In contrast, T cells in rTG mice exhibited proliferation against both host-type C.B-17 and donor-type F344 rat cells. Consistently, graft-vs.-host disease symptoms developed in these mice and histological examination showed impressive infiltration of lymphocytes into the skin or into the mucosal layers of the stomach. Activated state of T cells in rTG mice was also evidence by the positive expression of interleukin-2 receptor. Taken together, fetal thymus appears to contain progenitor cells which are sufficient for in vivo reconstitution of T lymphopoiesis, but species-specific environment is important for the induction of tolerance. In mTG mice, V beta 6+ T cells reactive to donor Mlsa determinants and V beta 3+ T cells reactive to host Mlsc determinants were deleted, suggesting that tolerance was regulated mainly by clonal deletion. By contrast, V beta 11+ T cells reactive to Mlsf determinants were not deleted possibly due to the lack of their ligands.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3151-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8258329-Animals,
pubmed-meshheading:8258329-Clonal Deletion,
pubmed-meshheading:8258329-Graft vs Host Disease,
pubmed-meshheading:8258329-Hematopoiesis,
pubmed-meshheading:8258329-Lymphocyte Activation,
pubmed-meshheading:8258329-Mice,
pubmed-meshheading:8258329-Mice, Inbred AKR,
pubmed-meshheading:8258329-Mice, Inbred C57BL,
pubmed-meshheading:8258329-Mice, SCID,
pubmed-meshheading:8258329-Phenotype,
pubmed-meshheading:8258329-Rats,
pubmed-meshheading:8258329-Rats, Inbred F344,
pubmed-meshheading:8258329-Superantigens,
pubmed-meshheading:8258329-T-Lymphocytes,
pubmed-meshheading:8258329-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8258329-Thymus Gland,
pubmed-meshheading:8258329-Transplantation, Heterologous,
pubmed-meshheading:8258329-Transplantation, Homologous
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Development of T cells in SCID mice grafted with fetal thymus from AKR mice or F344 rats.
|
| pubmed:affiliation |
Department of Parasitology and Immunology, School of Medicine, University of Tokushima, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|