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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-1-10
|
| pubmed:abstractText |
To assess the role of genetic regulation as a modulating factor in the variability of rat tissue galactose-1-phosphate uridyltransferase (GALT) sp act, we have determined steady state GALT mRNA and sp act in rat liver during postnatal development. Steady state GALT mRNA levels increase from birth to d 5 and subsequently decrease toward adult levels. GALT sp act mirrors the mRNA pattern. A survey of steady state mRNA and GALT sp act of several adult rat tissues revealed marked tissue differences with a good correlation of the two parameters. Liver had the highest GALT mRNA and sp act; kidney, ovary, and heart had similar but lower mRNA and sp act; skeletal muscle and testes had the least GALT mRNA and enzyme sp act. These findings suggest that genetic regulation is important in the variable expression of GALT tissue sp act.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0031-3998
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
416-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8255669-Aging,
pubmed-meshheading:8255669-Animals,
pubmed-meshheading:8255669-Blotting, Northern,
pubmed-meshheading:8255669-Female,
pubmed-meshheading:8255669-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:8255669-Kidney,
pubmed-meshheading:8255669-Liver,
pubmed-meshheading:8255669-Lung,
pubmed-meshheading:8255669-Male,
pubmed-meshheading:8255669-Muscles,
pubmed-meshheading:8255669-Myocardium,
pubmed-meshheading:8255669-Organ Specificity,
pubmed-meshheading:8255669-Ovary,
pubmed-meshheading:8255669-RNA, Messenger,
pubmed-meshheading:8255669-Rats,
pubmed-meshheading:8255669-Rats, Sprague-Dawley,
pubmed-meshheading:8255669-Testis,
pubmed-meshheading:8255669-UTP-Hexose-1-Phosphate Uridylyltransferase
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Developmental and tissue-specific modulation of rat galactose-1-phosphate uridyltransferase steady state messenger RNA and specific activity levels.
|
| pubmed:affiliation |
Department of Pediatrics, University of Pennsylvania, Children's Hospital of Philadelphia 19104.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|