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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1994-1-12
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pubmed:abstractText |
1. The blood-cerebrospinal fluid (CSF) exchange of a wide range of passively transported lipid insoluble compounds (0.43-5.4 nm molecular radius) has been investigated in rats at different stages of postnatal development (2 days old to adult). A novel 'litter-based' model for investigating blood-CSF barrier exchange in immature animals is described. 2. At each age investigated there was a clear inverse correlation between molecular radius and blood-CSF barrier exchange, in addition to an overall decrease in blood-CSF barrier exchange with increasing age. 3. The decrease in blood-CSF barrier exchange with age was not consistent with a reduction in pore diameters, nor does it appear to be due to an increase in the CSF sink effect with age. It seems likely to be due to a relative decrease in the number of a population of large diameter pores.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-1004553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-1151440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-1293278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-13088295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-14244077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-1895237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-22861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-3986606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-4199658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-4452410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-4456012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-4601383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-490348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-4956917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-5505536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-575326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-5795246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-6155468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8254533-6368666
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
468
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-83
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:8254533-Animals,
pubmed-meshheading:8254533-Biological Markers,
pubmed-meshheading:8254533-Blood-Brain Barrier,
pubmed-meshheading:8254533-Brain,
pubmed-meshheading:8254533-Cerebrospinal Fluid,
pubmed-meshheading:8254533-Diffusion,
pubmed-meshheading:8254533-Immunoglobulin G,
pubmed-meshheading:8254533-Inulin,
pubmed-meshheading:8254533-Models, Biological,
pubmed-meshheading:8254533-Permeability,
pubmed-meshheading:8254533-Rats,
pubmed-meshheading:8254533-Solubility,
pubmed-meshheading:8254533-Sucrose
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pubmed:year |
1993
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pubmed:articleTitle |
The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.
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pubmed:affiliation |
Clinical Neurological Sciences (Developmental) Group, Faculty of Medical Sciences, Southampton General Hospital.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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