Linked Life Data

8254332

Source:http://linkedlifedata.com/resource/pubmed/id/8254332

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-1-13
pubmed:abstractText
Thermodynamic parameters for magnesium binding to a series of DNA molecules of defined sequence have been evaluated by 25Mg NMR spectroscopy. These results demonstrate that G/C-DNA binds Mg2+(aq) up to 40 to 100-fold more strongly than A/T-DNA, i.e., coordination of Mg2+(aq) to G/C-DNA is ca. 2.1-2.7 kcal (mole Mg2+)-1 more stable relative to A/T-DNA. Activation free energies [delta G* approximately (12.7-13.3) x 10(3) kcal] and exchange rates [k(ex) approximately (0.5-3.0) x 10(3)s-1] were estimated by variable temperature experiments. The low value of the quadrupole coupling constants (chi B = 0.2-0.6 MHz) is indicative of outer-sphere coordination by Mg(H2O)6(2+).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0162-0134
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Sequence selective coordination of Mg2+(aq) to DNA.
pubmed:affiliation
Evans Laboratory of Chemistry, Ohio State University, Columbus 43210.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't