Linked Life Data

8254226

Source:http://linkedlifedata.com/resource/pubmed/id/8254226

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-1-11
pubmed:abstractText
Much evidence now exists that tumors possess specific antigens recognizable by T cells. The goal of immunotherapy is to break tolerance to these antigens while preserving self-tolerance. Recently, newer approaches have been developed in animal systems that modify tumor cells genetically so that they express new antigens or secrete certain cytokines. Engineering tumor cells to secrete cytokines in a paracrine fashion can induce powerful local cytokine effects which, in addition to inducing local inflammation, can alter the presentation of tumor antigens or the activation of tumor-antigen-specific T lymphocytes, resulting in systemic antitumor immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0257-277X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-92
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The antitumor immune response as a problem of self-nonself discrimination: implications for immunotherapy.
pubmed:affiliation
Department of Oncology, Medicine and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196.
pubmed:publicationType
Journal Article, Review