Linked Life Data

8252845

Source:http://linkedlifedata.com/resource/pubmed/id/8252845

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-1-11
pubmed:abstractText
The effect of age on growth hormone (GH) metabolism and GH-releasing factor (GRF)-induced GH concentrations were studied in 7 young (3 mo, 39 kg) and 7 old (30 mo, 156 kg) Yorkshire x Landrace female pigs. Jugular catheters were surgically inserted and 60 hr later total serum volume was determined. The following day, all animals were infused for 3 hr with GH (30.3 ng.min/kg B.W.) in order to calculate GH metabolic clearance rate (MCR), secretion rate (SR) and half-life (t 1/2). Two days later, 15 micrograms/kg of GRF was injected i.v. into all pigs. On a per animal basis, aging increased (P < .01) MCR (299 vs 132 ml/min), SR (714 vs 422 ng/min) and serum volume (6.6 vs 2.01), whereas t1/2 was unaltered (P > .1). Basal GH concentrations were lower in older pigs (P < .10) but the GRF-induced GH concentrations (measured as GH peak or area under the curve, AUC) were not affected by age (P > .1). Yet, when induced total GH secretion (AUC x MCR) and average total serum GH (mean GH post-injection x serum volume) were calculated per pig, these variables significantly increased between 3 and 30 mo of age. Basal IGF-I concentrations were lower in older pigs (P < .01), yet, there was a tendency (P = .10) for these pigs to show a greater IGF-I response to GH infusion. The present data therefore indicate that age alters both SR and post-secretory metabolism of GH.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0739-7240
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Age-related changes in secretion rate and post-secretory metabolism of growth hormone in swine.
pubmed:affiliation
Agriculture Canada, Research Station, Lennoxville, Québec, Canada.
pubmed:publicationType
Journal Article