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rdf:type |
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lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0024264,
umls-concept:C0205419,
umls-concept:C0681850,
umls-concept:C0871261,
umls-concept:C0882989,
umls-concept:C1519885,
umls-concept:C1550501,
umls-concept:C1704632,
umls-concept:C1706203,
umls-concept:C1706817,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
1994-1-11
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pubmed:abstractText |
Previous work in our laboratory has shown that lymphocytes from persons vaccinated with a formalin-inactivated Phase I Q fever vaccine (Q-Vax CSL Ltd) show a mitogenic response to Coxiella burnetii antigens. The mitogenic response is the sum of that from various subsets of CD4+, T helper cells, CD8+ T cells and probably B cells. It does not distinguish between T helper cell responses leading to formation of interferon-gamma (IFN-gamma)--a cytokine responsible for clearing intracellular infection with C. burnetii organisms--and responses of other T cell subsets which may produce disease-enhancing cytokines. The present study analyses (i) the capacity of Q-Vax to induce T cell sensitization which leads to IFN-gamma responses on antigen stimulation, and (ii) the immunomodulatory, (down-regulatory) effects of the Phase I lipopolysaccharide (LPS) of the organism, which interacts with monocyte/macrophages to limit IL-2 production and production of IFN-gamma by sensitized T lymphocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1112616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-115919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-13458182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1388655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1418371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1680337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1714473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1831489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-1958288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2070564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2323360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2415642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2528896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2575073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2575116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2576587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2663725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2745570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2871125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2890808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2903212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2932612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-2960769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-3104476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-3155770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-3346570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-3957431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-4401569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-6195938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-6350491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-6432701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-686359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-6977613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8252811-730352
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
507-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8252811-Antigens, Bacterial,
pubmed-meshheading:8252811-Bacterial Vaccines,
pubmed-meshheading:8252811-Cells, Cultured,
pubmed-meshheading:8252811-Coxiella burnetii,
pubmed-meshheading:8252811-Down-Regulation,
pubmed-meshheading:8252811-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8252811-Fluorescent Antibody Technique,
pubmed-meshheading:8252811-Humans,
pubmed-meshheading:8252811-Immunoenzyme Techniques,
pubmed-meshheading:8252811-Interferon-gamma,
pubmed-meshheading:8252811-Interleukin-2,
pubmed-meshheading:8252811-Lipopolysaccharides,
pubmed-meshheading:8252811-Lymphocyte Activation,
pubmed-meshheading:8252811-Macrophages,
pubmed-meshheading:8252811-Monocytes,
pubmed-meshheading:8252811-Q Fever,
pubmed-meshheading:8252811-T-Lymphocytes,
pubmed-meshheading:8252811-Vaccination
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pubmed:year |
1993
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pubmed:articleTitle |
Variation in interferon-gamma responses to Coxiella burnetii antigens with lymphocytes from vaccinated or naturally infected subjects.
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pubmed:affiliation |
Department of Pathology, University of Adelaide, South Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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