Linked Life Data

8248349

Source:http://linkedlifedata.com/resource/pubmed/id/8248349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-1-3
pubmed:abstractText
The effects of RU 486, a potent glucocorticoid antagonist, on dietary fat preference were explored in obese men and lean controls in a double-blind crossover study. An oral 10 mg/kg dose of RU 486 or placebo was administered at midnight the second night of a 48-h hospital stay. Macronutrient and caloric intakes were calculated each day and a taste test of six commercial dairy products (fat content by weight < 0.5%, 2.0%, 3.3%, 10.5%, 18%, and 36%) was performed. Dairy products were judged for pleasantness, creaminess, and overall preference. Subjects were then asked to consume their favorite dairy product until sated. Urinary free cortisol (UFC) and plasma adrenocorticotropic hormone (ACTH), cortisol, insulin, and glucose were determined. Intake of a self-selected diet was recorded. As expected, in response to RU 486, UFC increased from 120 +/- 25 micrograms/24 h to 297 +/- 73 micrograms/24 h (p < 0.05) in obese men and from 81 +/- 10 micrograms/24 h to 357 +/- 109 micrograms/24 h (p < 0.05) in lean men. Plasma cortisol increased from 26.1 +/- 1.1 microgram/dl to 31.8 +/- 1.0 microgram/dl (p < 0.05) in obese men and from 26.1 +/- 1.7 micrograms/dl to 32.2 +/- 1.7 micrograms/dl (p < 0.05) in lean men. Plasma insulin was significantly higher in obese 24.6 +/- 3.2 microIU/ml than in lean men 12.8 +/- 1.1 microIU/ml (p = 0.0001) but was unaffected by RU 486. RU 486 did not decrease fat intake in either obese or lean men.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
717-24
pubmed:dateRevised
2011-11-17
pubmed:otherAbstract
PIP: In genetically obese rats and mice, either an elevated or increased sensitivity to plasma glucocorticoids has been associated with obesity and with increased dietary fat preference. In order to determine whether a similar relationship exists in humans, the dietary fat preference of fasted obese men given an acute dose of RU-486 was compared to that of fasted lean men treated with RU-486 or a placebo. The 10 overweight and 12 normal weight adult men recruited for the study were required to spend 2 48-hour periods a week apart in the hospital. 26 hours after admission, patients received either 10 mg/kg body weight of RU-486 or a placebo and then they fasted overnight. The next day, they were given 6 dairy products with different levels of fat (1, 2, 4, 10.5, 18, and 36%). The samples were identified only by number. The subjects judged the samples on pleasantness, creaminess, and overall preference. They then consumed their favorite until sated. Micronutrient and caloric intakes were calculated each day and urinary free cortisol, plasma adrenocorticotropic hormone, cortisol, insulin, and glucose were determined. Urinary free cortisol increased significantly after the single dose of RU-486 as compared to values the day before or the day after treatment. No differences were found during control periods or between lean and obese men. Plasma cortisol concentration also increased significantly after RU-486 administration. RU-486 did not affect plasma insulin concentration or plasma adrenocorticotropic hormone. In addition, RU-486 did not decrease fat intake in any of the subjects. Treatment had no affect on dairy product preference or on ability to judge the level of creaminess (fat) in the different samples. The only significant result of the taste test was that there was a positive correlation between urinary free cortisol and fat intake in obese men during placebo periods when the product chosen was consumed. Further research is necessary to determine the relationship between cortisol and fat intake in obese humans, and chronic studies of glucocorticoid blockade with RU-486 would be helpful.
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men.
pubmed:affiliation
Department of Nutrition and Food Science, University of Maryland, College Park 20742.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial