| pubmed-article:8248215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C0553662 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C1527180 | lld:lifeskim |
| pubmed-article:8248215 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:8248215 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:8248215 | pubmed:dateCreated | 1994-1-4 | lld:pubmed |
| pubmed-article:8248215 | pubmed:abstractText | The characteristic histopathology and major histocompatibility complex associations in juvenile rheumatoid arthritis suggest an oligoclonal antigen-specific T-cell population may be critical to pathogenesis. To test this, we analyzed the T-cell repertoire of a polyarticular HLA-DR4+ juvenile rheumatoid arthritis patient with an aggressive form of disease that required arthrocentesis of the knee joints and early replacement of both hip joints. A comparison of T-cell-receptor beta chain variable region (V beta) gene expression in peripheral blood and synovial fluid performed by semiquantitation of cDNA samples amplified by the PCR revealed overexpression of the T-cell-receptor V beta 14 gene family. To determine the nature of V beta 14 overexpression, we sequenced randomly cloned amplification products derived from two synovial fluid, two synovial tissue, and three peripheral blood samples by using a V beta 14/beta chain constant region primer pair. Sequence data showed that the T-cell response in the synovia was oligoclonal. Of four clones found, one was present in all joints examined and persisted over time. This clone accounted for 67% and 74% of all V beta 14+ clones sequenced in two synovial fluid samples and 75% and 40% in two synovial tissue samples. This clone was also found at a lesser frequency in peripheral blood samples. Further studies provided evidence for the presence of oligoclonally expanded populations of T cells utilizing the V beta 14 T-cell receptor in 6 of 27 patients examined. In contrast to the remaining patients studied, 3 with a late onset polyarticular course who exhibited especially marked clonality were characterized by features typical of adult rheumatoid arthritis (IgM rheumatoid factor-positive and HLA-DR4+). These data suggest a role for V beta 14+ T cells in a group of juvenile rheumatoid arthritis patients. | lld:pubmed |
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| pubmed-article:8248215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8248215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8248215 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8248215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8248215 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8248215 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8248215 | pubmed:author | pubmed-author:ChoaMM | lld:pubmed |
| pubmed-article:8248215 | pubmed:author | pubmed-author:GlassD NDN | lld:pubmed |
| pubmed-article:8248215 | pubmed:author | pubmed-author:ThompsonS DSD | lld:pubmed |
| pubmed-article:8248215 | pubmed:author | pubmed-author:LuyrinkLL | lld:pubmed |
| pubmed-article:8248215 | pubmed:author | pubmed-author:GromA AAA | lld:pubmed |
| pubmed-article:8248215 | pubmed:author | pubmed-author:PassoMM | lld:pubmed |
| pubmed-article:8248215 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8248215 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8248215 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8248215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8248215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8248215 | pubmed:pagination | 11104-8 | lld:pubmed |
| pubmed-article:8248215 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8248215 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8248215 | pubmed:articleTitle | Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. | lld:pubmed |
| pubmed-article:8248215 | pubmed:affiliation | Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229-3039. | lld:pubmed |
| pubmed-article:8248215 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8248215 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8248215 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8248215 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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