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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
1993-12-28
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pubmed:abstractText |
Subsequent of the discovery that RNA can have site specific cleavage activity, there has been a great deal of interest in the design and testing of trans-acting catalytic RNAs as therapeutic agents. We have chemically synthesized and experimentally analyzed chimeric DNA-RNA ribozymes in which the catalytic center remains as RNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0261-3166
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-6
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:8247757-Base Sequence,
pubmed-meshheading:8247757-Catalysis,
pubmed-meshheading:8247757-Hydrolysis,
pubmed-meshheading:8247757-Hydroxyl Radical,
pubmed-meshheading:8247757-Kinetics,
pubmed-meshheading:8247757-Molecular Sequence Data,
pubmed-meshheading:8247757-Nucleic Acid Conformation,
pubmed-meshheading:8247757-Purines,
pubmed-meshheading:8247757-Pyrimidines,
pubmed-meshheading:8247757-RNA, Catalytic
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pubmed:year |
1993
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pubmed:articleTitle |
Importance of specific purine-pyrimidine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.
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pubmed:affiliation |
Department of Industrial Chemistry, Chiba Institute of Technology, Japan.
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pubmed:publicationType |
Journal Article
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