Linked Life Data

8247268

Source:http://linkedlifedata.com/resource/pubmed/id/8247268

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-1-5
pubmed:abstractText
The clinical potential of transplants of fetal dopaminergic neurons is limited by the fact that the percentage of cells surviving in such grafts is in general quite low. This report investigates the use of basic fibroblast growth factor administration (given either as a pretreatment or by repeated intrastriatal infusions) to promote the survival and behavioural efficacy of embryonic dopamine-rich nigral transplants in rats. Pretreatment of the graft tissue by brief incubation with basic fibroblast growth factor increased the survival of tyrosine hydroxylase-immunoreactive (presumed dopaminergic) neurons in the grafts in comparison to control grafts, and accelerated the recovery in the transplanted animals in tests of drug-induced rotational asymmetry. However, the clear advantage seen in the rotation test conducted three weeks after transplantation had disappeared by nine weeks. The moderate effects of pretreatment were markedly enhanced by repeated intrastriatal infusion of basic fibroblast growth factor into the host animals over 20 days following transplantation. This resulted in > 100% increase in the number of dopaminergic neurons surviving in the grafts, and was accompanied by a significantly greater recovery of the rats' rotational asymmetries which persisted over the full nine weeks of testing. However, the repeated intracerebral infusions induced an inflammatory reaction in the striatum, and the associated trauma both complicates the interpretation of the mechanism of observed recovery and compromises the utility of this route of basic fibroblast growth factor administration for promoting graft survival.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-98
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons--II. Effects on nigral transplants in vivo.
pubmed:affiliation
MRC Cambridge Centre for Brain Repair, University of Cambridge, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't