Linked Life Data

824713

Source:http://linkedlifedata.com/resource/pubmed/id/824713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6-7
pubmed:dateCreated
1977-1-3
pubmed:abstractText
In a search for H- or L-chain-related cross-idiotypic specificity among human anti-I and anti-i cold agglutinins, two idiotypic antisera raised against the IgMkappa cold agglutinin Da were tested for their binding activity to isolated cold agglutinin H and L chains. Negligible H-chain binding activity was found, but there was high-titre L-chain binding activity in one of the antisera. This was an unsuspected VkappaIII subgroup activity which enabled the classification of VkappaIII proteins into three subgroups. The kappa chains of five out of six anti-I and anti-i cold agglutinins belonged to the antigenically most active VkappaIII subgroup. Absorption of the idiotypic antiserum with a Bence Jones protein of this latter subgroup did not appreciably alter the precipitating cross-idiotypic activity of the antiserum when tested with intect cold agglutinins. However, these studies do not rule out the possible existence of a VkappaIII subgroup-associated conformational antigen in an intact Fab region, which is seen as a 'cross idiotypic' antigen by heterologous (rabbit anti-human) antisera.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-36
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Kappa chain (V kappa III) subgroup-related activity in an idiotypic anti-cold agglutinin serum.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.