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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-1-6
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/A23669,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L08176,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L09230,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60626,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M62505,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64749,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M68932,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M73696,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M73969,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M84562,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M99293,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/P09704,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S09941,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X17403,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X68149
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pubmed:abstractText |
Chemokines are pro-inflammatory molecules with a diverse array of biological and biochemical functions. These molecules induce the migration of a number of leukocyte subsets including monocytes, neutrophils, and T-cells. The recent cloning of the IL-8, GRO, and MIP-1 alpha chemokine receptors revealed that these glycoproteins belong to the serpentine family of seven transmembrane G-protein-coupled receptors. Other members of this family include the chemotactic receptors for fMLP and C5a, indicating that a common pathway for eliciting the directional migration of leukocytes is probably transduced via G proteins. Ligand binding to chemokine receptors is complex, featured by multiple chemokines binding to a single receptor and multiple receptors binding a specific ligand. Future directions in this field appear to be focused on the cloning of novel receptors and the identification of ligands for orphaned receptors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
604-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
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pubmed:year |
1993
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pubmed:articleTitle |
Chemokines and serpentines: the molecular biology of chemokine receptors.
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pubmed:affiliation |
Laboratory of Immunoregulation, Frederick Cancer Research and Development Center, Maryland 21702.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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