Linked Life Data

8245531

Source:http://linkedlifedata.com/resource/pubmed/id/8245531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-12-28
pubmed:abstractText
Primary neonatal murine astrocyte cultures were used to investigate the role of these glial cells in host defense of the central nervous system (CNS) against Toxoplasma gondii. For comparison, neonatal murine microglial cells were also studied. Microscopic analyses revealed that uptake of T. gondii into astrocytes was parasite-driven and was followed by uniform intracellular survival and multiplication of tachyzoites. Treatment of astrocytes with interferon (IFN)-gamma and lipopolysaccharide (LPS) had no apparent effect on the survival or growth of T. gondii. Microglia, on the other hand, had both an intrinsic phagocytosis-associated antitoxoplasma activity and a nitric oxide-dependent inhibitory activity that was up-regulated by IFN-gamma and LPS. The results of this study suggest that in contrast to microglial cells, astrocytes may provide a safe harbor within the CNS for T. gondii.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1472-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Intracellular survival and multiplication of Toxoplasma gondii in astrocytes.
pubmed:affiliation
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, Minnesota.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.