| pubmed-article:8245523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0009450 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0020517 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1272753 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0085432 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1414406 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C1171370 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:8245523 | lifeskim:mentions | umls-concept:C0015737 | lld:lifeskim |
| pubmed-article:8245523 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8245523 | pubmed:dateCreated | 1993-12-28 | lld:pubmed |
| pubmed-article:8245523 | pubmed:abstractText | Recombinant gp160 derived from human immunodeficiency virus type 1 (HIV-1)IIIB and produced in mammalian tissue culture cells using a vaccinia virus expression system (rgp160-mam) was evaluated as a vaccine in combination with alum and deoxycholate adjuvant. Sixty low-risk, uninfected subjects received 12.5 micrograms, 50.0 micrograms, or adjuvant control at 0, 1, 6, and 12 months in a randomized, double-blind dose-escalation study. A single injection of 200 micrograms of vaccine was given at 18 months in an open study to 9 vaccines who had received 50 micrograms. The vaccine was safe. Six of 16 subjects receiving 50 micrograms developed neutralizing antibody to HIV-1IIIB. Seven of the 9 boosted with 200 micrograms of vaccine at 18 months developed neutralizing antibodies. Lymphocyte proliferation to rgp160-mam and baculovirus-derived rgp160 and rgp120 was induced in both groups (12.5 and 50.0 micrograms) and appeared after the first dose. Further studies with higher doses of rgp160-mam and vaccines derived from other strains of HIV-1 are warranted. | lld:pubmed |
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| pubmed-article:8245523 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8245523 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8245523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8245523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8245523 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8245523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8245523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8245523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8245523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8245523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8245523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8245523 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8245523 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:WrightPP | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:BelsheR BRB | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:DolinRR | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:SchwartzDD | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:GrahamB SBS | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:CoreyLL | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:ClementsM LML | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:GorseG JGJ | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:KeeferM CMC | lld:pubmed |
| pubmed-article:8245523 | pubmed:author | pubmed-author:McElrathJJ | lld:pubmed |
| pubmed-article:8245523 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8245523 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:8245523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8245523 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8245523 | pubmed:pagination | 1387-95 | lld:pubmed |
| pubmed-article:8245523 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8245523 | pubmed:meshHeading | pubmed-meshheading:8245523-... | lld:pubmed |
| pubmed-article:8245523 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8245523 | pubmed:articleTitle | Safety and immunogenicity of a fully glycosylated recombinant gp160 human immunodeficiency virus type 1 vaccine in subjects at low risk of infection. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group Network. | lld:pubmed |
| pubmed-article:8245523 | pubmed:affiliation | Dept. of Medicine, St. Louis University School of Medicine, MO 63104. | lld:pubmed |
| pubmed-article:8245523 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8245523 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8245523 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8245523 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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