Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1993-12-23
|
| pubmed:abstractText |
In a screen of pradimicin-nonproducing mutants derived from Actinomadura verrucosospora subsp. neohibisca R103-3, we found a strain capable of producing 11-hydroxyl analogs of pradimicins A and FA-1, designated pradimicins H and FH, respectively. Feeding of pradimicins H and FH to growing cultures of an actinomycete strain AA3798 produced 11-O-L-xylosylpradimicins H and FH, respectively. These 11-O-L-xylosylpradimicins had a broad spectrum of antifungal activity and demonstrated in vivo efficacies against Candida albicans in mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1589-97
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8244888-Actinomyces,
pubmed-meshheading:8244888-Animals,
pubmed-meshheading:8244888-Anthracyclines,
pubmed-meshheading:8244888-Antibiotics, Antineoplastic,
pubmed-meshheading:8244888-Antifungal Agents,
pubmed-meshheading:8244888-Candidiasis,
pubmed-meshheading:8244888-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8244888-Male,
pubmed-meshheading:8244888-Mice,
pubmed-meshheading:8244888-Mice, Inbred ICR,
pubmed-meshheading:8244888-Microbial Sensitivity Tests,
pubmed-meshheading:8244888-Structure-Activity Relationship
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Microbial modification of pradimicins at C-11 leading to 11-O-demethyl- and 11-O-L-xylosylpradimicins A and FA-1.
|
| pubmed:affiliation |
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|