|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008838,
umls-concept:C0013089,
umls-concept:C0013216,
umls-concept:C0015385,
umls-concept:C0025677,
umls-concept:C0029463,
umls-concept:C0030705,
umls-concept:C0205225,
umls-concept:C0205421,
umls-concept:C0332283,
umls-concept:C0332293,
umls-concept:C0444956,
umls-concept:C0543467,
umls-concept:C1274040,
umls-concept:C1518409
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1993-12-23
|
|
pubmed:abstractText |
Neoadjuvant chemotherapy is the most accepted treatment for localized osteosarcoma. This has led to a great improvement in limb-sparing surgery and in disease-free survival. Patients with a good response to preoperative chemotherapy showed a higher disease-free survival rate. Current studies examine the possibility of patients whose limbs could be rescued with a poor necrosis and a reduction of the side effects related to aggressive treatments.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0008-543X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
72
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3227-38
|
|
pubmed:dateRevised |
2010-3-24
|
|
pubmed:meshHeading |
pubmed-meshheading:8242546-Adolescent,
pubmed-meshheading:8242546-Adult,
pubmed-meshheading:8242546-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8242546-Bone Neoplasms,
pubmed-meshheading:8242546-Cisplatin,
pubmed-meshheading:8242546-Combined Modality Therapy,
pubmed-meshheading:8242546-Doxorubicin,
pubmed-meshheading:8242546-Extremities,
pubmed-meshheading:8242546-Female,
pubmed-meshheading:8242546-Femur,
pubmed-meshheading:8242546-Humans,
pubmed-meshheading:8242546-Humerus,
pubmed-meshheading:8242546-Infusions, Intravenous,
pubmed-meshheading:8242546-Injections, Intra-Arterial,
pubmed-meshheading:8242546-Male,
pubmed-meshheading:8242546-Methotrexate,
pubmed-meshheading:8242546-Neoplasm Recurrence, Local,
pubmed-meshheading:8242546-Osteosarcoma,
pubmed-meshheading:8242546-Postoperative Complications,
pubmed-meshheading:8242546-Preoperative Care,
pubmed-meshheading:8242546-Remission Induction,
pubmed-meshheading:8242546-Survival Rate,
pubmed-meshheading:8242546-Tibia
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities. Results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin.
|
|
pubmed:affiliation |
Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
