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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8 Suppl
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pubmed:dateCreated |
1994-1-4
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pubmed:abstractText |
Nine patients who underwent heart transplantation (one female; average age 48 +/- 11, range 19-58 years) were followed in respect to contents of right-sided heart septum, blood and plasma ubiquinone (UQ), plasma alpha-tocopherol (alpha T), and plasma free cholesterol (FC). In contrast to healthy persons, substantial inter- and intraindividual variations were observed; individually low values were seen with rejection. Heart muscle UQ in well-treated patients averaged 0.33 +/- 0.08, range 0.06-0.58 micrograms mg-1 (0.38 +/- 0.09 mumol g-1 dry weight) and was not different from healthy individuals. Plasma UQ, alpha T; and FC averaged 0.63 +/- 0.33 micrograms ml-1 (P < 0.05 versus sedentary controls), 8.1 +/- 4.0 micrograms ml-1 (P < 0.01), and 0.52 +/- 0.23 mg ml-1 (P < 0.05). Corresponding molar values were 0.73 +/- 0.37 (UQ), 2.0 +/- 1.1 mumol l-1 (alpha T), and 1.42 +/- 0.54 mmol l-1 (FC). Blood and plasma UQ values were identical. A saturation like relationship was found between heart and blood UQ:blood contents below 0.7 micrograms ml-1 (0.8 mumol l-1) corresponded to markedly lowered heart contents. In four patients in whom blood samples were taken close to a fatal complication it averaged 0.42 micrograms ml-1 (0.49 mumol l-1, P < 0.01). When low heart muscle and blood ubiquinone were present, other variables such as left ventricle cardiac output or cycle ergometer performance was markedly impaired. Plasma UQ and alpha T covaried with a marker of the lipoidal deposit volume, plasma FC.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0941-0198
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S76-83
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8241710-Adult,
pubmed-meshheading:8241710-Exercise Test,
pubmed-meshheading:8241710-Female,
pubmed-meshheading:8241710-Heart Transplantation,
pubmed-meshheading:8241710-Humans,
pubmed-meshheading:8241710-Longitudinal Studies,
pubmed-meshheading:8241710-Male,
pubmed-meshheading:8241710-Middle Aged,
pubmed-meshheading:8241710-Myocardium,
pubmed-meshheading:8241710-Oxidation-Reduction,
pubmed-meshheading:8241710-Ubiquinone,
pubmed-meshheading:8241710-Vitamin E
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pubmed:year |
1993
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pubmed:articleTitle |
Heart muscle ubiquinone and plasma antioxidants following cardiac transplantation.
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pubmed:affiliation |
Department of Clinical Physiology, Karolinska Institute, Stockholm.
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pubmed:publicationType |
Journal Article
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