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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1994-1-4
|
| pubmed:abstractText |
The susceptibility of low-density lipoprotein (LDL) to oxidation was studied in hypertriglyceridemic men (5 with type III and 5 with type IV) at baseline on a low-saturated-fat, low-cholesterol diet, after 6 weeks of dietary supplementation with fish oil (Promega, 12 g/d), and after 6 weeks of fish oil combined with probucol (500 mg BID). The relative content of n-3 polyunsaturated fatty acids in plasma and LDL was increased during the two treatment periods, and a low alpha-tocopherol to n-3 polyunsaturated fatty acids ratio was observed. Plasma thiobarbituric acid-reactive substances (TBARS) levels were unchanged after 6 weeks of fish oil, but the ratio of lipid peroxides to the reduced triglyceride (TG) levels (MDA:TG) was significantly higher (P < .01). Addition of probucol lowered both absolute levels of TBARS (P < .01) and the MDA to TG ratio (P < .001). The susceptibility of LDL to Cu(2+)-catalyzed oxidation was evaluated over a 5-hour time course by determining TBARS formation, free amino group levels, and changes in LDL electrophoretic mobility. TBARS levels that were higher in native LDL (1.019 < d < 1.050 g/mL) after 6 weeks of fish oil than at baseline (P < .01) were reduced 52.3 +/- 11.3% by the addition of probucol (P < .001). With fish oil alone, TBARS production after exposure of LDL to Cu2+ for 5 hours was increased 17.0 +/- 5.8% compared with corresponding baseline values (P < .001), whereas a 64.1 +/- 14.3% reduction from the previous period was observed with fish oil + probucol (P < .001).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Fish Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Probucol,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/cupric chloride,
http://linkedlifedata.com/resource/pubmed/chemical/very low density lipoprotein...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1049-8834
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1790-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8241099-Adult,
pubmed-meshheading:8241099-Antioxidants,
pubmed-meshheading:8241099-Cholesterol, HDL,
pubmed-meshheading:8241099-Cholesterol, VLDL,
pubmed-meshheading:8241099-Copper,
pubmed-meshheading:8241099-Fish Oils,
pubmed-meshheading:8241099-Humans,
pubmed-meshheading:8241099-Hyperlipoproteinemia Type III,
pubmed-meshheading:8241099-Hyperlipoproteinemia Type IV,
pubmed-meshheading:8241099-Lipid Peroxidation,
pubmed-meshheading:8241099-Lipoproteins, LDL,
pubmed-meshheading:8241099-Lipoproteins, VLDL,
pubmed-meshheading:8241099-Male,
pubmed-meshheading:8241099-Middle Aged,
pubmed-meshheading:8241099-Probucol,
pubmed-meshheading:8241099-Thiobarbituric Acid Reactive Substances,
pubmed-meshheading:8241099-Triglycerides,
pubmed-meshheading:8241099-Vitamin E
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients.
|
| pubmed:affiliation |
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Québec, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|