|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1994-1-3
|
|
pubmed:abstractText |
A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0266-9536
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
257-68
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8240655-Animals,
pubmed-meshheading:8240655-Antineoplastic Agents,
pubmed-meshheading:8240655-Humans,
pubmed-meshheading:8240655-Imides,
pubmed-meshheading:8240655-Intercalating Agents,
pubmed-meshheading:8240655-Isoquinolines,
pubmed-meshheading:8240655-Mice,
pubmed-meshheading:8240655-Naphthalenes,
pubmed-meshheading:8240655-Naphthalimides,
pubmed-meshheading:8240655-Neoplasms, Experimental,
pubmed-meshheading:8240655-Structure-Activity Relationship,
pubmed-meshheading:8240655-Tumor Cells, Cultured
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Bis-naphthalimides: a new class of antitumor agents.
|
|
pubmed:affiliation |
Laboratorios Knoll S. A, Madrid, Spain.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
