Linked Life Data

8240339

Source:http://linkedlifedata.com/resource/pubmed/id/8240339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-12-9
pubmed:abstractText
HNP-1 [correction of NHP-1], a member of a family of microbicidal cationic, cystine-rich polypeptides abundant in the azurophilic granules of polymorphonuclear leukocytes (PMN) interfered with detergent-induced cell-free activation of superoxide-producing NADPH oxidase. IC50 of 3 microM has been evaluated for this dose dependent effect of defensin. Preactivated oxidase was not affected by HNP-1. The inhibitory effect could be relieved by raising the concentration of the cytosol or by the addition of a partially purified p47-phox. NADPH oxidase activated in the presence of HNP-1 exhibited an increased affinity for NADPH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
636-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Defensin interferes with the activation of neutrophil NADPH oxidase in a cell-free system.
pubmed:affiliation
Department of Biochemistry, Faculty of Life Sciences, Tel-Aviv University, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't