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pubmed-article:8239627pubmed:abstractTextAt nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-11 pth(Ts) cells at nonpermissive temperatures. Erythromycin and lincomycin also stimulated the accumulation of peptidyl-tRNA. Lincomycin and clindamycin stimulated peptidyl-tRNA dissociation from ribosomes.lld:pubmed
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pubmed-article:8239627pubmed:articleTitleLincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.lld:pubmed
pubmed-article:8239627pubmed:affiliationDepartment of Biological Sciences, University of Iowa, Iowa City 52242-1324.lld:pubmed
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