Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5A
|
| pubmed:dateCreated |
1993-12-17
|
| pubmed:abstractText |
An alpha-mannosidase inhibitor, mannostatin A, from Streptoverticillium verticillus var. quintum inhibited chemotactic invasion of mouse B16/F10 melanoma cells in the Boyden chamber assay. It also inhibited in vitro invasion of K-ras-NIH3T3 cells. Mannostatin A did not inhibit the growth of either cell line at the concentration effective to inhibit invasion. Addition of mannostatin A to the cultured B16/F10 or K-ras-NIH3T3 cells inhibited cellular alpha-mannoside activity specifically. Mannostatin A-treated B16/F10 cells also showed decreased metastatic activity in vivo in C57Bl/6 mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0250-7005
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1421-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8239514-3T3 Cells,
pubmed-meshheading:8239514-Animals,
pubmed-meshheading:8239514-Cyclopentanes,
pubmed-meshheading:8239514-Diffusion Chambers, Culture,
pubmed-meshheading:8239514-Female,
pubmed-meshheading:8239514-Lung Neoplasms,
pubmed-meshheading:8239514-Mannosidases,
pubmed-meshheading:8239514-Melanoma,
pubmed-meshheading:8239514-Mice,
pubmed-meshheading:8239514-Mice, Inbred C57BL,
pubmed-meshheading:8239514-Neoplasm Invasiveness,
pubmed-meshheading:8239514-Tumor Cells, Cultured
|
| pubmed:articleTitle |
Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A.
|
| pubmed:affiliation |
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
|
| pubmed:publicationType |
Journal Article
|