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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 1
|
| pubmed:dateCreated |
1993-12-22
|
| pubmed:abstractText |
Because mesangial expansion is considered a precursor of focal glomerulosclerosis, we studied whether morphine can cause mesangial expansion. We used radiolabeled human immunoglobulin G aggregates (125I-ahIgG) to study mesangial kinetics in control and experimental (morphine-treated) rats. Control and experimental rats were administered 125I-ahIgG by tail vein. Serum levels of 125I-ahIgG and uptake of 125I-ahIgG by liver, spleen, and mesangium were determined at 4, 8, 12, 24, and 36 h after 125I-ahIgG administration. Mesangial 125I-ahIgG levels were higher (P < 0.05) at 4 h and at later periods in morphine-treated vs. control rats. Naloxone, an opioid antagonist, did not attenuate the morphine-induced mesangial accumulation of 125I-ahIgG. The mean uptake of IgG aggregates was lower in the liver and spleen of morphine-treated rats at 36 h (P < 0.05). In both in vivo and in vitro experiments, ultrastructural studies showed accumulation of IgG-coated gold particles in vesicles, endosomes, and lysosomes. Morphine may have increased the accumulation of 125I-ahIgG in the glomeruli either by increasing the delivery of macromolecules into the mesangium or by altering the exit of macromolecules from the mesangium.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-9513
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
265
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
C1211-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8238474-Animals,
pubmed-meshheading:8238474-Biological Transport,
pubmed-meshheading:8238474-Cells, Cultured,
pubmed-meshheading:8238474-Dogs,
pubmed-meshheading:8238474-Glomerular Mesangium,
pubmed-meshheading:8238474-Humans,
pubmed-meshheading:8238474-Immunoglobulin G,
pubmed-meshheading:8238474-Iodine Radioisotopes,
pubmed-meshheading:8238474-Kinetics,
pubmed-meshheading:8238474-Liver,
pubmed-meshheading:8238474-Lung,
pubmed-meshheading:8238474-Macrophages,
pubmed-meshheading:8238474-Male,
pubmed-meshheading:8238474-Microscopy, Electron,
pubmed-meshheading:8238474-Microscopy, Electron, Scanning,
pubmed-meshheading:8238474-Morphine,
pubmed-meshheading:8238474-Naloxone,
pubmed-meshheading:8238474-Phagocytosis,
pubmed-meshheading:8238474-Rats,
pubmed-meshheading:8238474-Rats, Sprague-Dawley,
pubmed-meshheading:8238474-Spleen,
pubmed-meshheading:8238474-Tissue Distribution
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effect of morphine on mesangial immunoglobulin G aggregate kinetics.
|
| pubmed:affiliation |
Department of Medicine and Pathology, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|