Linked Life Data

8237282

Source:http://linkedlifedata.com/resource/pubmed/id/8237282

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-12-7
pubmed:abstractText
The assumption that the oxidation of lipoproteins plays an eminent role in the development of atherosclerosis is of increasing significance. Our examinations concerned the kinetics of lipid peroxidation of the poly-unsaturated fatty acids in lipoproteins and the existing protection mechanisms by antioxidants, such as vitamin E and carotenoids. Clinical studies proving a correlation of plasma levels and antioxidants, such as vitamin C and E and carotenoids in correlation with cardiovascular disease are cited and discussed. Certain aldehydes originating during lipid peroxidation in LDL modify the protein part of LDL. The consequence of the oxidative modification of LDL is a decreased recognition of LDL by the LDL-receptor and moreover the uptake by macrophages hereby changing to foam cells. Epitopes as developed in oxidatively modified LDL were also shown immunohistochemically in atherosclerotic plaques. Finally a hypothetic scheme is presented how LDL is oxidized in the vessel wall and how it initiates processes resulting in atherosclerosis.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-8173
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Oxidized lipoproteins and atherogenesis].
pubmed:affiliation
Institut für Medizinische Biochemie, Karl-Franzens-Universität, Graz.
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't