Linked Life Data

8236379

Source:http://linkedlifedata.com/resource/pubmed/id/8236379

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-12-1
pubmed:abstractText
In persons naturally exposed to high transmission, how significant, in terms of immune protection, is the occurrence or non-occurrence of a malaria attack during a given observation period? This question was studied in a West African village where Plasmodium falciparum malaria is holoendemic with intense and perennial transmission. A cohort of 94 children aged 4 months-14 years from Dielmo village, Sénégal, was studied over 4 months, June-September 1990. 41 children had no malaria attack and 53 children suffered between one and 6 attacks. The average number of attacks was 1.80, 2.25, 1.87, 0.29 and 0.07, respectively, in children aged 4-11 months, 1-2, 3-6, 7-10 and 11-14 years. The transmission level was 75 infective bites per person. Analysis of the distribution of the number of attacks in individual children suggested that all children within the same age group had either the same, or a very similar, level of protection. This suggests that the acquisition of clinical protection in areas where malaria is highly endemic involves a progressive and homogeneous decrease of the probability of having a malaria attack (attacks occur less frequently as age increases, in all children), rather than the acquisition of complete protection by an increasing number of children. The differences between the number of clinical attacks observed in young children and their presumed exposure suggest that protective mechanisms become effective from the first reinfection onwards, and are independent of the cumulative exposure to a great variety of antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0035-9203
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Malaria attacks in children exposed to high transmission: who is protected?
pubmed:affiliation
Service d'Epidémiologie, Institut Pasteur, Dakar, Sénégal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't