Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-12-7
|
| pubmed:abstractText |
Thrombomodulin (TM) is an endothelial cell membrane glycoprotein which neutralizes thrombin procoagulant activity and accelerates the thrombin-catalyzed activation of protein C. We expressed recombinant human soluble TM (rhs-TM) in Chinese hamster ovary cells and compared the effects of rhs-TM and heparin on endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. Experimental DIC was induced by a continuous intravenous infusion of endotoxin for four hours. rhs-TM or heparin was infused simultaneously with endotoxin. Treatment with rhs-TM significantly reversed the endotoxin-induced changes in significantly reversed the endotoxin-induced changes in following parameters: platelet count, fibrinogen level and fibrinogen and fibrin degradation products. Furthermore, glomerular fibrin deposits elevated by endotoxin treatment were reduced by the rhs-TM administration. Heparin showed the similar effects to rhs-TM. Activated partial thromboplastin time (APTT) in rats receiving rhs-TM were slightly longer than APTT in endotoxin-treated rats, but rats receiving heparin had much more prolonged APTT. From these results, we concluded that rhs-TM may be useful for the clinical treatment of DIC while having only minor adverse effects on APTT.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrin,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrin Fibrinogen Degradation...,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolytic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombomodulin,
http://linkedlifedata.com/resource/pubmed/chemical/endotoxin, Escherichia coli
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0049-3848
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
325-35
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8236161-Animals,
pubmed-meshheading:8236161-Disseminated Intravascular Coagulation,
pubmed-meshheading:8236161-Dose-Response Relationship, Drug,
pubmed-meshheading:8236161-Endotoxins,
pubmed-meshheading:8236161-Female,
pubmed-meshheading:8236161-Fibrin,
pubmed-meshheading:8236161-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:8236161-Fibrinogen,
pubmed-meshheading:8236161-Fibrinolytic Agents,
pubmed-meshheading:8236161-Humans,
pubmed-meshheading:8236161-Infusions, Intravenous,
pubmed-meshheading:8236161-Kidney Glomerulus,
pubmed-meshheading:8236161-Partial Thromboplastin Time,
pubmed-meshheading:8236161-Prothrombin Time,
pubmed-meshheading:8236161-Rats,
pubmed-meshheading:8236161-Rats, Wistar,
pubmed-meshheading:8236161-Recombinant Proteins,
pubmed-meshheading:8236161-Thrombomodulin
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats.
|
| pubmed:affiliation |
Institute for Life Science Research, Asahi Chemical Industry, Shizuoka, Japan.
|
| pubmed:publicationType |
Journal Article
|