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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1993-12-9
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pubmed:abstractText |
Polyclonal activation of B-lymphocytes accompanies many retroviral infections. Friend derived murine immunosuppressive virus (Fd-MIV) is a non-defective murine retrovirus which was isolated from T-helper cells from mice infected with the acute transforming retrovirus Friend leukaemia complex (FLC). In contrast to FLC, Fd-MIV does not induce acute transformation of lymphoid and erythroid cells but causes immunosuppression and lymphadenopathy in adult NMRI mice. The effect of Fd-MIV infection on B-lymphocytes was studied. Fd-MIV infection led to a persistent hypergammaglobulinemy with a significant increase in the level of circulating IgG, IgM and immune complexes. In the spleen and lymph nodes, B-lymphocyte proliferation was found. Parallel to the development of hypergammaglobulinemy, autoantibodies to a variety of nuclear and other autoantigens was detected. In conclusion, the Fd-MIV infection leads to a B-lymphocyte dysfunction that has many parallels with AIDS. Furthermore, the Fd-MIV infection seems to represent an example of an autoimmune condition caused by an exogenous infectious agent.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0300-9475
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-62
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8235449-Animals,
pubmed-meshheading:8235449-Antigen-Antibody Complex,
pubmed-meshheading:8235449-Autoantibodies,
pubmed-meshheading:8235449-Autoimmunity,
pubmed-meshheading:8235449-B-Lymphocytes,
pubmed-meshheading:8235449-Female,
pubmed-meshheading:8235449-Friend murine leukemia virus,
pubmed-meshheading:8235449-Hypergammaglobulinemia,
pubmed-meshheading:8235449-Immunoglobulin G,
pubmed-meshheading:8235449-Immunoglobulin M,
pubmed-meshheading:8235449-Immunosuppression,
pubmed-meshheading:8235449-Lymph Nodes,
pubmed-meshheading:8235449-Lymphocyte Activation,
pubmed-meshheading:8235449-Mice,
pubmed-meshheading:8235449-Mice, Inbred NZB,
pubmed-meshheading:8235449-Retroviridae Infections,
pubmed-meshheading:8235449-Spleen
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pubmed:year |
1993
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pubmed:articleTitle |
Polyclonal activation of B-lymphocytes and induction of autoimmunity in retrovirus infected NMRI mice.
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pubmed:affiliation |
Institute of Cancer Research, University of Trondheim, Norway.
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pubmed:publicationType |
Journal Article
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