Linked Life Data

8233534

Source:http://linkedlifedata.com/resource/pubmed/id/8233534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-11-29
pubmed:abstractText
The putative central analgesic activity of diclofenac was investigated in a human experimental pain model using intraneural electrical stimulation in the median nerve. Since pain is induced proximal to the peripheral nociceptors, the model can be used to test central analgesic properties of i.a. pharmacological interventions performed during series of repeated stimulations. A single intravenous dose of 50 mg diclofenac or saline was administered during an ongoing series of painful intraneural stimulations in a double-blind cross-over study in 10 healthy volunteers. Neither diclofenac nor saline caused any significant change in the level of pain experienced during stimulation. Thus, no central analgesic effect of diclofenac could be demonstrated in this model. The stability of individual visual analogue scale (VAS) scores throughout the experimental sessions, also after administration of the potent peripheral analgesic agent diclofenac, underlines the validity of intraneural stimulation as a central pain model in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3959
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-202
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Diclofenac evaluated in a human experimental model of central pain.
pubmed:affiliation
Department of Clinical Pharmacology, Sahlgrens' Hospital, Göteborg, Sweden.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial