|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1993-12-13
|
|
pubmed:abstractText |
Intravitreal injection of antibiotics has become a standard therapy for bacterial endophthalmitis. The duration of effective antimicrobial levels in the vitreous after single injection, however, may not be long enough to get optimal response. The authors prepared liposome-encapsulated amikacin for prolonging the duration of intravitreal therapeutic concentrations and investigated the intravitreal pharmacokinetics of the liposomes and amikacin in phosphate buffer solution (PBS) as control.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0161-6420
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
100
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1640-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8233389-Absorption,
pubmed-meshheading:8233389-Amikacin,
pubmed-meshheading:8233389-Animals,
pubmed-meshheading:8233389-Disease Models, Animal,
pubmed-meshheading:8233389-Drug Carriers,
pubmed-meshheading:8233389-Endophthalmitis,
pubmed-meshheading:8233389-Eye Infections, Bacterial,
pubmed-meshheading:8233389-Fluorescence Polarization Immunoassay,
pubmed-meshheading:8233389-Half-Life,
pubmed-meshheading:8233389-Liposomes,
pubmed-meshheading:8233389-Rabbits,
pubmed-meshheading:8233389-Random Allocation,
pubmed-meshheading:8233389-Staphylococcal Infections,
pubmed-meshheading:8233389-Staphylococcus aureus,
pubmed-meshheading:8233389-Vitrectomy,
pubmed-meshheading:8233389-Vitreous Body
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Intravitreal pharmacokinetics of liposome-encapsulated amikacin in a rabbit model.
|
|
pubmed:affiliation |
Department of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan, People's Republic of China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
