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rdf:type |
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lifeskim:mentions |
umls-concept:C0017287,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0036576,
umls-concept:C0205263,
umls-concept:C0439064,
umls-concept:C0441471,
umls-concept:C0524889,
umls-concept:C0851346,
umls-concept:C1336745,
umls-concept:C1522642,
umls-concept:C1704387
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pubmed:issue |
11
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pubmed:dateCreated |
1993-12-3
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16595,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16596,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16597,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16598,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16599,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16600,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16601,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16602,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16603,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16604,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16605,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16606,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D16607
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pubmed:abstractText |
After split-dose irradiation, pre-lymphoma cells develop from a tumor-specific surface antigen TL-2+ thymocyte subpopulation. To analyze the clonality of pre-lymphoma cells, various numbers of TL-2+ thymocytes from a single irradiated mouse were intra-thymically injected to Thyl congenic recipient mice. The incidence of donor type thymic lymphoma(s) was subsequently examined in a group of recipient mice. We chose several lymphomas derived from a single donor mouse and analyzed the TCR gene rearrangements and V(D)J junctional diversity as genetic markers of clonality. These results indicate multiple initial neoplastic events and clonal selection into lymphoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
959-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8231236-Amino Acid Sequence,
pubmed-meshheading:8231236-Animals,
pubmed-meshheading:8231236-Antigens, Neoplasm,
pubmed-meshheading:8231236-Base Sequence,
pubmed-meshheading:8231236-Blotting, Southern,
pubmed-meshheading:8231236-Clone Cells,
pubmed-meshheading:8231236-Female,
pubmed-meshheading:8231236-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:8231236-Genetic Markers,
pubmed-meshheading:8231236-Lymphoma, T-Cell,
pubmed-meshheading:8231236-Mice,
pubmed-meshheading:8231236-Molecular Sequence Data,
pubmed-meshheading:8231236-Neoplasm Transplantation,
pubmed-meshheading:8231236-Neoplasms, Radiation-Induced,
pubmed-meshheading:8231236-Precancerous Conditions
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pubmed:year |
1993
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pubmed:articleTitle |
Multiple pre-neoplastic events and clonal selection of radiation induced mouse thymic lymphomas shown by TCR gene rearrangements.
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pubmed:affiliation |
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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