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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1993-12-21
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pubmed:abstractText |
Adenovirus E4orf4 protein was previously shown to counteract transactivation of junB by cyclic AMP (cAMP) and E1A protein. It was also shown to cause hypophosphorylation of E1A and c-Fos proteins. Here we show that the E4orf4 protein associates with protein phosphatase 2A. All three subunits of the phosphatase are present in the complex, and the B subunit interacts directly with the viral protein. The complex possesses a phosphatase activity typical of protein phosphatase 2A, and the phosphatase mediates the E4orf4-induced down regulation of junB transcription. Thus, adenovirus E4orf4 protein recruits protein phosphatase 2A into a signal transduction pathway initiated by cAMP and E1A protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1325671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1326648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1330540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1334231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1352481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1370560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1623517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1654119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1656238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1716348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1825028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-1846321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2143697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2153055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2154696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2157202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2158158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2288874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2536934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2549856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2554323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2557326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2559873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2850966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2985384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-2985385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-3052279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-3313383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-5439579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-620421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-8380637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-8382567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-8383623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8230475-8384305
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7556-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8230475-Adenovirus E1A Proteins,
pubmed-meshheading:8230475-Adenovirus E4 Proteins,
pubmed-meshheading:8230475-Animals,
pubmed-meshheading:8230475-Base Sequence,
pubmed-meshheading:8230475-Down-Regulation,
pubmed-meshheading:8230475-Macromolecular Substances,
pubmed-meshheading:8230475-Mice,
pubmed-meshheading:8230475-Molecular Sequence Data,
pubmed-meshheading:8230475-Phosphoprotein Phosphatases,
pubmed-meshheading:8230475-Promoter Regions, Genetic,
pubmed-meshheading:8230475-Protein Phosphatase 2,
pubmed-meshheading:8230475-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:8230475-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.
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pubmed:affiliation |
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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