Linked Life Data

823034

Source:http://linkedlifedata.com/resource/pubmed/id/823034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1976-12-3
pubmed:abstractText
We investigated in detail the cation requirements of two different systems of mouse cell-mediated cytolysis in vitro, at their recognition, post-recognition hit and target cell disintegration stages. In T cell-mediated cytolysis, respectively Mg++ or Ca++, Ca++, and no cations, were required. In non-T cell-mediated hemolysis, respectively no cations, Mg++, and no cations, were required. Two main conclusions can be drawn. First, the cation requirements are different from one system to the other especially at the post-recognition hit stage, which strongly suggests the existence of differences between both systems as to the actual mechanism of lysis. Second, the cation requirements are different within each system from one step to another. This formed the basis of a step-by-step analysis of the lytic process, leading to the characterization of a cation pulse method for the experimental isolation and further study of the post-recognition hit stage of cell-mediated cytolysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
The lethal hit stage of mouse T and non-T cell-mediated cytolysis: differences in cation requirements and characterization of an analytical "cation pulse" method.
pubmed:publicationType
Journal Article