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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1993-12-10
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pubmed:abstractText |
Chiral HPLC resolution of the phosphodiesterase IV (PDE IV) inhibitor rolipram (1) provided (-)-1, and this enantiomer was converted into its 1-(4-bromobenzyl) derivative, (+)-2. X-ray structural analysis of (+)-2 established the absolute configuration as R, which provides the first direct evidence for a previously assumed assignment of configuration. The crystal structure of (+)-2 and the PDE inhibitory activity of both enantiomers of 2 are discussed in the context of a previously proposed topological model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3274-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8230117-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:8230117-Animals,
pubmed-meshheading:8230117-Benzyl Compounds,
pubmed-meshheading:8230117-Cattle,
pubmed-meshheading:8230117-Crystallography, X-Ray,
pubmed-meshheading:8230117-Molecular Conformation,
pubmed-meshheading:8230117-Muscle, Smooth,
pubmed-meshheading:8230117-Phosphodiesterase Inhibitors,
pubmed-meshheading:8230117-Pyrrolidinones,
pubmed-meshheading:8230117-Rolipram,
pubmed-meshheading:8230117-Stereoisomerism
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pubmed:year |
1993
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pubmed:articleTitle |
The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one.
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pubmed:affiliation |
Department of Physical and Structural Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
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pubmed:publicationType |
Journal Article
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