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pubmed-article:8230097pubmed:abstractTextThe binding modes of a series of penicillin-derived C2 symmetric dimer inhibitors of HIV-1 proteinase were investigated by NMR, protein crystallography, and molecular modeling. The compounds were found to bind in a symmetrical fashion, tracing and S-shaped course through the active site, with good hydrophobic interactions in the S1/S1' and S2/S2' pockets and hydrogen bonding of inhibitor amide groups. Interactions with the catalytic aspartates appeared poor and the protein conformation was very similar to that seen in complexes with peptidomimetics, in spite of the major differences in ligand structure.lld:pubmed
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pubmed-article:8230097pubmed:articleTitleA series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies.lld:pubmed
pubmed-article:8230097pubmed:affiliationProtein Structure Group, Glaxo Group Research Limited, Greenford, Middlesex, United Kingdom.lld:pubmed
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