| pubmed-article:8229171 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8229171 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8229171 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8229171 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:8229171 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:8229171 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8229171 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:8229171 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8229171 | pubmed:dateCreated | 1993-12-17 | lld:pubmed |
| pubmed-article:8229171 | pubmed:abstractText | 1. Conventional intracellular recordings were performed in rat hippocampal slices to investigate the electrophysiological properties of subicular neurons. These cells had a resting membrane potential (RMP) of -66 +/- 7.2 mV (mean +/- SD; n = 50), input resistance of 23.6 +/- 8.2 M omega (n = 51), time constant of 7.1 +/- 1.9 ms (n = 51), action potential amplitude of 85.8 +/- 13.8 mV (n = 50), and duration of 2.9 +/- 1.2 ms (n = 48). Analysis of the current-voltage relationship revealed membrane inward rectification in both depolarizing and hyperpolarizing direction. The latter type was readily abolished by Cs+ (3 mM; n = 6 cells). 2. Injection of depolarizing current pulses of threshold intensity induced in all subicular neurons (n = 51) recorded at RMP a burst of two to three fast action potentials (frequency = 212.7 +/- 90 Hz, n = 13 cells). This burst rode on a slow depolarizing envelope and was followed by an afterhyperpolarization and later by regular spiking mode once the pulse was prolonged. Similar bursts were also generated upon termination of a hyperpolarizing current pulse. 3. The slow depolarization underlying the burst resembled a low-threshold response, which in thalamic cells is caused by a Ca2+ conductance and is contributed by the Cs(+)-sensitive inward rectifier. However, bursts in subicular cells persisted in medium containing the Ca(2+)-channel blockers Co2+ (2 mM) and Cd2+ (1 mM) (n = 5 cells) but disappeared during application of TTX (1 microM; n = 3 cells). Hence they were mediated by Na+. Blockade of the hyperpolarizing inward rectification by Cs+ did not prevent the rebound response (n = 3 cells). 4. Our findings demonstrate that intrinsic bursts, presumably related to a "low-threshold" Na+ conductance are present in rat subicular neurons. Similar intrinsic characteristics have been suggested to underlie the rhythmic activity described in other neuronal networks, although in most cases the low-threshold electrogenesis was caused by Ca2+. We propose that the bursting mechanism might play a role in modulating incoming signals from the classical hippocampal circuit within the limbic system. | lld:pubmed |
| pubmed-article:8229171 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8229171 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8229171 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8229171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8229171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8229171 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8229171 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8229171 | pubmed:issn | 0022-3077 | lld:pubmed |
| pubmed-article:8229171 | pubmed:author | pubmed-author:AvoliMM | lld:pubmed |
| pubmed-article:8229171 | pubmed:author | pubmed-author:HwaG GGG | lld:pubmed |
| pubmed-article:8229171 | pubmed:author | pubmed-author:MattiaDD | lld:pubmed |
| pubmed-article:8229171 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8229171 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8229171 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8229171 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8229171 | pubmed:pagination | 1244-8 | lld:pubmed |
| pubmed-article:8229171 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8229171 | pubmed:meshHeading | pubmed-meshheading:8229171-... | lld:pubmed |
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| pubmed-article:8229171 | pubmed:meshHeading | pubmed-meshheading:8229171-... | lld:pubmed |
| pubmed-article:8229171 | pubmed:meshHeading | pubmed-meshheading:8229171-... | lld:pubmed |
| pubmed-article:8229171 | pubmed:meshHeading | pubmed-meshheading:8229171-... | lld:pubmed |
| pubmed-article:8229171 | pubmed:meshHeading | pubmed-meshheading:8229171-... | lld:pubmed |
| pubmed-article:8229171 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8229171 | pubmed:articleTitle | Membrane properties of rat subicular neurons in vitro. | lld:pubmed |
| pubmed-article:8229171 | pubmed:affiliation | Montreal Neurological Institute, McGill University, Quebec, Canada. | lld:pubmed |
| pubmed-article:8229171 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8229171 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8229171 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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