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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-12-14
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pubmed:abstractText |
To confirm the possibility that some hepatitis B virus (HBV) variants do not induce HB s antigen (HBsAg), anti-HB core antibody (anti-HBc) and anti-HBc IgM in a transient infection, polymerase chain reaction (PCR) was performed in 20 patients with acute hepatitis and 7 patients with fulminant hepatitis. Patients were diagnosed with non-A, non-B hepatitis by serological markers at admission. PCR successfully amplified the precore/core gene in 5 (25%) of the patients with acute hepatitis and 2 (29%) of the patients with fulminant hepatitis. Subsequent sequencing revealed frequent mutations including precore-defects in the precore/core gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-72
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8228132-Acute Disease,
pubmed-meshheading:8228132-Adult,
pubmed-meshheading:8228132-Amino Acid Sequence,
pubmed-meshheading:8228132-Base Sequence,
pubmed-meshheading:8228132-DNA, Viral,
pubmed-meshheading:8228132-Female,
pubmed-meshheading:8228132-Genome, Viral,
pubmed-meshheading:8228132-Hepatitis Antibodies,
pubmed-meshheading:8228132-Hepatitis B,
pubmed-meshheading:8228132-Hepatitis B Core Antigens,
pubmed-meshheading:8228132-Hepatitis B Surface Antigens,
pubmed-meshheading:8228132-Hepatitis B virus,
pubmed-meshheading:8228132-Humans,
pubmed-meshheading:8228132-Immunoglobulin M,
pubmed-meshheading:8228132-Middle Aged,
pubmed-meshheading:8228132-Molecular Sequence Data,
pubmed-meshheading:8228132-Mutation,
pubmed-meshheading:8228132-Polymerase Chain Reaction,
pubmed-meshheading:8228132-Radioimmunoassay,
pubmed-meshheading:8228132-Viral Core Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Detection of precore/core-mutant hepatitis B virus genome in patients with acute or fulminant hepatitis without serological markers for recent HBV infection.
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pubmed:affiliation |
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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