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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-12-14
|
| pubmed:abstractText |
Recently antibodies to hepatitis C virus were detected in sera of chronic active hepatitis patients, with anti-smooth muscle autoantibodies or with anti-liver/kidney microsomal type 1 autoantibodies. As the latter were used to differentiate autoimmune chronic active hepatitis from chronic non-A, non-B virus hepatitis, it was mainly important to discover if autoantibodies were associated with chronic hepatitis C virus infection. The sera of 272 chronic hepatitis C patients were screened by indirect immunofluorescence for non-organ specific autoantibodies. Antinuclear antibodies and anti-smooth muscle autoantibodies were more frequent in chronic hepatitis C patients than in blood donors (n = 100). Anti-liver/kidney microsomal type 1 autoantibodies were not detected in the sera of the blood donors, in the 74 hepatitis B patients or in the 30 alcoholic hepatitis or cirrhotic patients' sera tested as controls. They were detected in 14 chronic hepatitis C patients. These antibodies were compared in immunodiffusion to anti-liver/kidney microsomal type 1 autoantibodies sera obtained from type-2 autoimmune chronic active hepatitis patients and an identity reaction was observed. Chronic hepatitis C patients without or with anti-liver/kidney microsomal type 1 autoantibodies, did not differ in age, sex ratio, transaminases and gammaglobulin level, risk factors for hepatitis C virus infection, association with other autoimmune diseases. These patients differed significantly from type-2 autoimmune chronic active hepatitis patients. We conclude that: (i) in some chronic hepatitis C patients the pattern and the titer of autoantibodies may create confusion with an autoimmune chronic active hepatitis; (ii) There is no serological evidence for a hepatitis C virus infection in true type-2 autoimmune chronic active hepatitis.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0168-8278
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
359-64
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8228130-Adolescent,
pubmed-meshheading:8228130-Adult,
pubmed-meshheading:8228130-Age Factors,
pubmed-meshheading:8228130-Aged,
pubmed-meshheading:8228130-Antibodies,
pubmed-meshheading:8228130-Antibodies, Antinuclear,
pubmed-meshheading:8228130-Autoantibodies,
pubmed-meshheading:8228130-Child,
pubmed-meshheading:8228130-Child, Preschool,
pubmed-meshheading:8228130-Chronic Disease,
pubmed-meshheading:8228130-Cytosol,
pubmed-meshheading:8228130-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8228130-Fluorescent Antibody Technique,
pubmed-meshheading:8228130-Hepatitis C,
pubmed-meshheading:8228130-Humans,
pubmed-meshheading:8228130-Immunodiffusion,
pubmed-meshheading:8228130-Infant,
pubmed-meshheading:8228130-Liver,
pubmed-meshheading:8228130-Middle Aged,
pubmed-meshheading:8228130-Muscle, Smooth,
pubmed-meshheading:8228130-Organ Specificity,
pubmed-meshheading:8228130-Sex Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
|
| pubmed:affiliation |
Service d'Immunologie et d'Hématologie Biologique, Hôpital Saint-Antoine, Rothschild, France.
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| pubmed:publicationType |
Journal Article
|