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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31
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pubmed:dateCreated |
1993-11-29
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pubmed:abstractText |
Phosphotyrosine-containing synthetic peptides were used to identify the binding sites for cellular polypeptides involved in nerve growth factor receptor/Trk-mediated signal transduction. In vitro association of SHC and the p85 subunit of phosphatidylinositol 3'-kinase with the Trk tyrosine kinase was prevented only by phosphorylated Y-490- and Y-751-containing peptides, respectively. In spite of the close proximity of the p85 binding site to that of phospholipase C gamma (Y-785), both target proteins are able to interact with the same receptor molecule simultaneously.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
268
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pubmed:geneSymbol |
trk
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22963-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8226808-Amino Acid Sequence,
pubmed-meshheading:8226808-Base Sequence,
pubmed-meshheading:8226808-Binding, Competitive,
pubmed-meshheading:8226808-Binding Sites,
pubmed-meshheading:8226808-Cell Line,
pubmed-meshheading:8226808-Humans,
pubmed-meshheading:8226808-Macromolecular Substances,
pubmed-meshheading:8226808-Molecular Sequence Data,
pubmed-meshheading:8226808-Mutagenesis, Site-Directed,
pubmed-meshheading:8226808-Oligodeoxyribonucleotides,
pubmed-meshheading:8226808-Peptide Fragments,
pubmed-meshheading:8226808-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:8226808-Phosphoproteins,
pubmed-meshheading:8226808-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:8226808-Proteins,
pubmed-meshheading:8226808-Proto-Oncogene Proteins,
pubmed-meshheading:8226808-Receptor, trkA,
pubmed-meshheading:8226808-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8226808-Receptors, Nerve Growth Factor,
pubmed-meshheading:8226808-Signal Transduction,
pubmed-meshheading:8226808-Structure-Activity Relationship
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pubmed:year |
1993
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pubmed:articleTitle |
Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.
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pubmed:affiliation |
Department of Molecular Biology, Max-Planck-Institut für Biochemie, Martinsried, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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