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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1993-12-7
|
| pubmed:abstractText |
Synthesis and antifungal activity of pradimicin analogs modified on the aglycone part is described. Upon modification studies at various sites of the aglycone part using pradimicin A (PRM A), C-11 position was found to be the sole site to be modified without loosing antifungal activity. Further modification studies at C-11 position were carried out with 11-OH derivative of pradimicin T1 (PRM T1) because of its easy availability. Among the compounds prepared, 11-demethoxy derivative of PRM A (12) and 11-O-ethyl (13) and 11-O-fluoroethyl (14) derivatives of PRM T1 showed promising antifungal activity comparable to that of PRM A.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1447-57
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8226323-Antibiotics, Antineoplastic,
pubmed-meshheading:8226323-Antifungal Agents,
pubmed-meshheading:8226323-Carbohydrate Sequence,
pubmed-meshheading:8226323-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8226323-Microbial Sensitivity Tests,
pubmed-meshheading:8226323-Molecular Sequence Data,
pubmed-meshheading:8226323-Molecular Structure
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Synthesis and antifungal activity of pradimicin derivatives. Modifications on the aglycone part.
|
| pubmed:affiliation |
Bristol-Myers Squibb Research Institute, Bristol-Myers Squibb K. K., Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|