Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1993-12-2
|
| pubmed:abstractText |
A probability-summation model is introduced to provide quantitative criteria for discriminating independent from interactive effects of multiple laser exposures on biological tissue. Data that differ statistically from predictions of the probability-summation model indicate the action of sensitizing (synergistic/positive) or desensitizing (hardening/negative) biophysical interactions. Interactions are indicated when response probabilities vary with changes in the spatial or temporal separation of exposures. In the absence of interactions, probability-summation parsimoniously accounts for "cumulative" effects. Data analyzed using the probability-summation model show instances of both sensitization and desensitization of retinal tissue by laser exposures. Other results are shown to be consistent with probability-summation. The relevance of the probability-summation model to previous laser-bioeffects studies, models, and safety standards is discussed and an appeal is made for improved empirical estimates of response probabilities for single exposures.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0017-9078
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
523-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1993
|
| pubmed:articleTitle |
Probability-summation model of multiple laser-exposure effects.
|
| pubmed:affiliation |
Optical Radiation Division, Armstrong Laboratory, Brooks Air Force Base, TX 78235-5215.
|
| pubmed:publicationType |
Journal Article
|