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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-12-3
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pubmed:abstractText |
To investigate the receptor-like molecule(s) for plasminogen (PGn) on the neuronal surface, the properties of binding of PGn to the plasma membrane of cultured embryonic rat neocortical neurons were investigated. [125I]PGn was found to specifically bind to the plasma membrane depending on the incubation temperature and time. The binding was also affected strongly by ionic strength and slightly by Ca2+. Furthermore, ligand blotting analysis revealed that [125I]PGn binds to a major protein with an apparent molecular weight of 45 kDa among plasma membrane proteins. These results suggest that the 45-kDa protein is a PGn receptor-like molecule on the neuronal surface.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
333
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8224183-Animals,
pubmed-meshheading:8224183-Cell Fractionation,
pubmed-meshheading:8224183-Cell Membrane,
pubmed-meshheading:8224183-Cells, Cultured,
pubmed-meshheading:8224183-Centrifugation, Density Gradient,
pubmed-meshheading:8224183-Cerebral Cortex,
pubmed-meshheading:8224183-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8224183-Embryo, Mammalian,
pubmed-meshheading:8224183-Kinetics,
pubmed-meshheading:8224183-Molecular Weight,
pubmed-meshheading:8224183-Neurons,
pubmed-meshheading:8224183-Plasminogen,
pubmed-meshheading:8224183-Povidone,
pubmed-meshheading:8224183-Rats,
pubmed-meshheading:8224183-Receptors, Cell Surface,
pubmed-meshheading:8224183-Receptors, Urokinase Plasminogen Activator,
pubmed-meshheading:8224183-Silicon Dioxide
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pubmed:year |
1993
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pubmed:articleTitle |
Plasminogen-binding protein associated with the plasma membrane of cultured embryonic rat neocortical neurons.
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pubmed:affiliation |
Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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