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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1993-12-14
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pubmed:databankReference |
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pubmed:abstractText |
We have previously characterized an infectious mouse mammary tumor virus [(MMTV(SW)] which induces a strong superantigen response in vivo. Here we describe the isolation and characterization of MMTV(C4) which was derived from milk of mice implanted with hyperplastic alveolar nodules. MMTV(C4) stimulates V beta 2 expressing T cells after local injection in vivo. Comparison with known open reading frame (orf) sequences revealed high homology to Mtv-6, an endogenous virus interacting with V beta 3-expressing T cells. The carboxyl-terminal amino acids were, however, altered. High homology including the carboxyl-terminal orf amino acids were found with MMTV(C3H-K). We show here that MMTV(C3H-K) has lost its superantigen function. Sequence comparisons permitted the characterization of few key amino acids which could be important for T cell receptor interaction and superantigen processing.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2765-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8223852-Amino Acid Sequence,
pubmed-meshheading:8223852-Animals,
pubmed-meshheading:8223852-Base Sequence,
pubmed-meshheading:8223852-DNA, Viral,
pubmed-meshheading:8223852-Female,
pubmed-meshheading:8223852-Hyperplasia,
pubmed-meshheading:8223852-Mammary Glands, Animal,
pubmed-meshheading:8223852-Mammary Neoplasms, Experimental,
pubmed-meshheading:8223852-Mammary Tumor Virus, Mouse,
pubmed-meshheading:8223852-Mice,
pubmed-meshheading:8223852-Mice, Inbred BALB C,
pubmed-meshheading:8223852-Milk,
pubmed-meshheading:8223852-Molecular Sequence Data,
pubmed-meshheading:8223852-Neoplasm Transplantation,
pubmed-meshheading:8223852-Precancerous Conditions,
pubmed-meshheading:8223852-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8223852-Sequence Deletion,
pubmed-meshheading:8223852-Viral Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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